New research reveals anti-cancer mechanism of exercise

Exercise can not only protect our motherland, but also protect ourselves. As we all know, exercise can prevent all kinds of diseases, large and small, and improve sleep. Some studies have found that the prognosis of cancer patients with exercise is better than that of non exercise. However, how this anti-cancer process works, especially in the biological mechanism, is still unknown. A reasonable explanation is that exercise can activate the immune system, thereby enhancing the body’s ability to prevent and inhibit cancer cell growth. Recently, an international research team led by Karolinska college in Sweden has elucidated the biological mechanism of anti-tumor exercise in a new study published on. The ability of T cells to recognize and clear cancer cells is the key to prevent tumor growth and is also the basis of immunotherapy. Exercise can indeed increase the activity of the immune system and make anti-tumor cells more effective, thus improving the effect of cancer treatment. The activity of immune cells is closely related to its metabolism. Many aspects of immunocytochemistry may be sensitive to exercise-induced metabolic changes. It is well known that exercise affects the function of immune cells, and the altered immune response is considered to be a potential mechanism for the effect of exercise on cancer risk and progression. Randall Johnson, co-author of the study and professor of cell and molecular biology at Karolinska college, said: “the biological mechanisms behind the positive effects of exercise can provide new insights into how the body maintains health and help us design and improve anti-cancer therapies.” < / P > < p > in this study, the researchers expanded this hypothesis by examining how cytotoxic T cells of the immune system respond to exercise. Cytotoxic T cell is a kind of specific T cell. It secretes various cytokines to participate in immune function. It has killing effect on some virus, tumor cells and other antigenic substances. It forms an important defense line of anti-virus and anti-tumor immunity with natural killer cells. < / P > < p > in view of the fact that the infiltration of cytotoxic T cells is associated with the good prognosis of many human tumors and some animal tumor models, researchers have paid special attention to the role of cytotoxic CD8 + T cells. < / P > < p > in this new study, the researchers divided tumor mice into two groups, one group voluntarily and regularly on the wheel, and the other group remained inactive. When mice exercise, tumor growth decreases. The researchers found that this is related to the level of circulating CD8 + T cells in the blood. The results showed that compared with the lazy mice, the growth of tumor in exercise mice was slow and the mortality rate was decreased. < / P > < p > to determine the role of exercise-induced CD8 + T cells in reducing tumor growth, the researchers tested the importance of anti-CD8 antibodies injected into exercise and lazy mice, which would remove CD8 + T cells in mice. The results showed that the antibody destroyed the positive effect of exercise on tumor growth and survival, which proved the importance of CD8 + T cells in tumor inhibition induced by exercise. < / P > < p > to study how exercise affects tumor growth, researchers isolated T cells, blood and tissue samples after exercise and measured the levels of common metabolites produced in muscles during exercise. The researchers found that these metabolites released by muscles into the blood during exercise make CD8 + T cells more effective, and some of these metabolites, such as lactic acid, alter the metabolism of T cells and increase their activity. The researchers also found that the metabolism of T cells isolated from exercise mice was altered compared with that of lazy mice. < / P > < p > in addition, the researchers also studied how these metabolites change after exercise. They took blood samples from eight healthy men who had been cycling for 30 minutes. They found that metabolites induced by exercise were also released in the body, and confirmed that strenuous exercise can change the metabolism of plasma and lymphatic organs. Helene rundqvist, the lead author of the study and a senior researcher in the Department of laboratory medicine at the Karolinska School of medicine, said: “our study shows that exercise can affect the production of several molecules and metabolites that activate anti-cancer immune cells, thereby inhibiting tumor growth. We hope that these findings will help us better understand how lifestyle affects our immune system and provide information for the development of new cancer immunotherapies Continue ReadingAmerican companies begin to give up R & D: who should pay for corporate research?