Science: great breakthrough! Cure malaria! Selective inhibition of pfclk3 protein can kill Plasmodium falciparum at all developmental stages

September 5, 2019 / BIOON / – – in a new study, researchers from research institutions such as the University of Glasgow in Scotland have made a breakthrough in revealing that a new drug called tcmdc-135051 may stop the spread of malaria and may also treat people infected with this deadly parasitic disease. These findings provide new hope for the global fight against malaria. The relevant research results were published in the Science Journal on August 30, 2019, with the title of “validation of the protein kinase pfclk3 as a multistage cross species malarial drug target”. The corresponding author of the paper is Professor Andrew Tobin of the University of Glasgow.

images from science, 2019, doi:10.1126/science.aau1682 。

malaria is an infectious disease transmitted by mosquitoes, which affects more than 200 million people and causes nearly 500000 deaths every year, most of them children.

malaria is caused by Plasmodium, which infects humans through mosquito bites. After infection, the parasite grows in red blood cells in the liver and blood. They can also change in the blood to take on male and female forms, which can be re infected when the mosquito bites and sucks blood from an infected person.

under the leadership of Professor Tobin, the researchers found a drug that can kill the parasite and prevent the sexual development of the parasite during all three stages of the life cycle of the parasite – the liver stage, the red blood cell stage and the gametophyte development stage (i.e. sexual development stage).

the new drug works by blocking the activity of an essential protein called pfclk3, which controls the production / activity of other proteins involved in keeping the parasite alive. By blocking the activity of the protein, the drug can effectively kill the parasite, not only to prevent its spread, but also to treat malaria patients.

Professor Tobin said: “we are very excited about these new discoveries and hope that they will pave the way for the first step in eliminating malaria. Our research shows that by killing the parasite at all stages of its development, we have not only found a potential cure for malaria, but also a way to prevent the spread of the parasite from humans to mosquitoes and then infect others. ”

the drug – a potent compound discovered by scientists after a rigorous screening process – has been heard to block the activity of the essential protein pfclk3. This protein is part of a system that controls the production of proteins in the parasite, and by inhibiting it, the parasites cannot produce many of the proteins necessary for their survival.

Professor Andy waters, co-author of the paper and director of the Wellcome integrated parasitology center at the University of Glasgow, said, “by inhibiting pfclk3, we have confirmed that the proteins necessary for the survival of the parasite have ceased to be produced, which will kill the Plasmodium at multiple developmental stages. In this way, we have found a way to stop the transmission of malaria parasites by killing the malaria parasites that infect mosquitoes, thereby preventing the transmission of malaria parasites between people (biogas

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Author: zmhuaxia