What diet anticancer? Nature: reducing serine intake can inhibit the growth of tumor cells

Also known as β – hydroxyalanine, like glycine and other nonessential amino acids, plays an important role in tumor growth. At present, limiting serine utilization has become a potential cancer treatment strategy. However, its molecular mechanism is still unclear, and the effect of serine on lipid metabolism is also unknown. < / P > < p > the researchers used [2,3-13c2] alanine to track alanine metabolism after inhibiting mitochondrial pyruvate carrier, and found that decreased alanine level was a potential mechanism for inhibiting MPC and enhancing anchoring independent growth. However, decreasing the level of serine inhibited the anchorage independent growth, which was similar to that of alanine supplementation. < / P > < p > in order to explore whether amino acid metabolism plays a role by regulating the synthesis of deoxysphingolipids, the researchers used polyglobin to target the function of serine palmitoyltransferase. The results showed that SPT could affect the synthesis of deoxyneurilein and anchor independent growth. Moreover, SPT has enzyme hybridity. It can not affect serine, but use alanine as the substrate to produce deoxysphingolipid and produce tumor cell growth. < / P > < p > the researchers further explored the role of serine, alanine and sphingolipid metabolism in the physiological environment in vivo. After HCT116 xenograft tumor mice were fed with control diet or allo nitrogen source diet lacking serine and glycine, it was found that the tumor size of SG diet mice was smaller, and the tumor size was negatively correlated with the duration of feeding SG feed. Moreover, restricting the intake of serine and glycine in diet will lead to the accumulation of deoxysphingolipid in tumor, which has adverse effects on tumor growth. < / P > < p > next, the researchers used polyglobin to inhibit the synthesis of SPT and deoxysphingolipids, and found that this treatment promoted the growth of HCT116 xenografts in mice fed – SG diet. Therefore, SPT integrates unique metabolic signals from glycolysis and mitochondria, affecting sphingolipid diversity and tumor progression. In conclusion, deoxysphingolipid can act as a stress signal to affect the composition of cell membrane and cell growth, while SPT is the “switch” of metabolic reaction in lipid group, which can inhibit tumor growth. Although further studies are needed to explain why these molecules are toxic to cancer cells, this study has proposed the possibility of interfering with tumor growth through diet, which has broad application prospects. Science Discovery